Publishers pdf, also known as version of record citation for published version apa. This article is from nature communications, volume 5. The adult flukes deposit fully developed eggs that are passed in the feces. Opisthorchis viverrini, a parasitic trematode, was recategorized as a group 1 biological carcinogen because it causes opisthorchiasis, which may result in cholangiocarcinoma. Opisthorchiasis viverrini is a common infection of the civet cat and other fisheating mammals, such as domestic cats and dogs reservoir final hosts, in cambodia. Please see additional file 1 for translations of the abstract into the five official working languages of the united nations. Files are available under licenses specified on their description page. The goal of this study was to develop the immunodiagnosis of opisthorchiasis using cathepsin f cysteine protease of o.
However, these helminths still exist and raise concerns regarding public. Opisthorchiasis is a parasitic disease that can infect fish eating mammals, including humans. Opisthorchiasis is an infection caused by either of the two parasite worms, the cat liver fluke, or scientifically called opisthorchis felineus also known as opisthorchis tenuicollis, or the southeast asian liver fluke called as opisthorchis viverrini. Although data from cambodia, laos and vietnam are rare, data from thailand often show wideranging. Refer to the help section for more detailed instructions.
Prevalence and associated risk factors of opisthorchis. Chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. Fish sharing as a risk factor for opisthorchis viverrini. Pdf opisthorchiasis caused by opisthorchis viverrini remains a major public health problem in many parts of southeast asia, including. Opisthorchis viverrini description, causes and risk factors. Chronic infection may lead to cholangiocarcinoma, a. Agent orange exposure cholangiocarcinoma bile duct liver.
A crosssectional study of 403 immigrant workers was conducted between october 2016 and june 2017 in nakhon ratchasima, thailand. We performed an epidemiologic survey of opisthorchiasis in yangon, myanmar. Opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis 1. The opisthorchis viverrini genome provides insights into. Opisthorchis viverrini, adult worm image from ash, 1997. Risk factors for opisthorchis viverrini infection in. Infection with opisthorchis viverrini and its associated cholangiocarcinoma cca is an underestimated problem in the mekong region of southeast asia, despite the widespread use of praziquantel. Author summary opistorchis viverrini is an important and neglected parasite affecting. In like fashion, diabetes mellitus is a major public health problem in this region and worldwide. Opisthorchis viverrini infection is highly prevalent in northeast thailand.
Microproteinuria during opisthorchis viverriniinfection. Parasites travel via the duodenum into the hosts intrahepatic or extrahepatic biliary ducts. Morfologicamente e muito semelhante ao opistorchis felineus, embora ligeiramente menor. Infection with opisthorchis viverrini and its associated cholangiocarcinoma cca is an underestimated problem in the mekong region of southeast asia, despite the widespread use of praziquantel and health education measures for parasite control. Opisthorchis viverrini ov, a human liver fluke, is a pathologically and economically important foodborne trematode. Research open access mothers opisthorchis viverrini. Abstractopisthorchiasis is a neglected, tropical disease caused by the carcinogenic asian liver fluke. The carcinogenic liver fluke opisthorchis viverrini is a reservoir for species of helicobacter quantitative real time pcr h. Apr 29, 2004 opisthorchis viverrini ov, a liver fluke, is endemic in the area, and has been evaluated as a cause of chca by international agency for research on cancer. In vitro diagnostic for the liver flukes opisthorchis. Pdf on jan 1, 2014, paiboon sithithaworn and others published opisthorchis viverrini and. A new strategy for controlling opisthorchiasis is needed because of issues such as drug resistance and reinfection. Liver fluke infection caused by opisthorchis viverrini is a major public health problem in thailand and adjacent countries.
The carcinogenic liver fluke opisthorchis viverrini is a reservoir for species of helicobacter asian pac j cancer prev, 16 5, 17511758 introduction cholangiocarcinoma cca is highly prevalent in asian. Ov, is a serious health problem of northeast, thailand. Opisthorchis viverrini is notable, because it is classi. Genetic variation in opisthorchis viverrini trematoda. Opisthorchis species are liver fluke parasites that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas in asia and europe where the parasite is found. Two important helminths, strongyloides stercoralis an intestinal roundworm and opisthorchis viverrini a liver fluke, are endemic in northeast thailand. Molecular changes in opisthorchis viverrini southeast asian liver. Endemicity of opisthorchis viverrini liver flukes, vietnam. Treatment of the liver fluke infection opisthorchis viverrini relies exclusively on praziquantel.
First report and molecular identification of opisthorchis. Opisthorchis viverrini, common name southeast asian liver fluke, is a trematode parasite from the family opisthorchiidae that attacks the area of the bile duct. Prevalence and associated risk factors of opisthorchis viverrini infections in rural communities along the nam kam river of northeastern thailand chuangchaiya, s. Opisthorchis viverrini is found mainly in northeast thailand, laos, cambodia, and central and southern vietnam. T cell deprivation appeared to have no effect on worm establishment or egg production. Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis specifically, opisthorchis viverrini and opisthorchis felineus. Liver flukes, such as clonorchis sinensis or opisthorchis viverrini, usually enter humans gastrointestinal tract after ingestion of raw fish or drinking of contaminated water. In 198081, the prevalence in the north, northeastern, centre. There have been national campaigns in place aimed at the control and eradication of soiltransmitted helminthiasis and opisthorchiasis in thailand for several decades. The liver fluke opisthorchis viverrini is a foodborne, zoonotic pathogen endemic to thailand and adjacent countries in southeast asia.
Jul 18, 2018 the liver flukes, opisthorchis viverrini and clonorchis sinensis, are known to cause cholangiocarcinoma cca, a type of liver cancer that develops within the bile duct. Fish intermediate hosts of the liver flukes a opisthorchis viverrini. This study is a crosssectionalanalytic study, aimed to determine actual levels of o. Permission is granted to copy, distribute andor modify this document under the terms of the gnu free documentation license, version 1. In thailand and neighbouring countries, human opisthorchiasis is caused by o. To combat and eventually eliminate the transmission of the liver fluke opisthorchis viverrini, an accurate and practical diagnostic test is required. Liver fluke infection caused by opisthorchis viverrini is a major public. The interrelationships of these two conditions were investigated in hamsters and in tissue cultures of. Secreted cysteine proteases of the carcinogenic liver fluke. Pcr diagnosis of opisthorchis viverrini and haplorchis. Author summary infection with the foodborne liver fluke opisthorchis viverrini frequently causes bile duct cancer, a prominent public health concern in the greater mekong subregion countries.
Opisthorchis viverrini is found in thailand and surrounding countries in southeast asia, whereas opisthorchis felineus is reported from eastern europe, siberia, and the european union. Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic asian liver fluke, opisthorchis viverrini. Foodborne trematodiasis fbt is a significant global health problem, with the liver flukes opisthorchis viverrini, o. The carcinogenic liver fluke opisthorchis viverrini is a. Secreted cysteine proteases of the carcinogenic liver fluke, opisthorchis viverrini. A total of 75 fecal specimens were analyzed by pcr following dna extraction. Opisthorchis viverrini an overview sciencedirect topics. Please see additional file 1 for translations of the abstract. In addition to infectionassociated morbidity, infection with o. Multilingual abstracts in the five official working languages of the united nations. Opisthorchis viverrini, common name southeast asian liver fluke, is a foodborne trematode parasite from the family opisthorchiidae that infects the bile duct.
A polymerase chain reaction pcr assay was evaluated for detection of opisthorchis viverrini eggs in the stool specimens of light and heavily infected individuals in khon kaen province of thailand. Ele vive no figado humano, sendo encontrado principalmente nas vias biliares e vesicula biliar, alimentase da bile. Numerous public health interventions have focused on reducing exposure to o. Comparing the performance of urine and coproantigen. A biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis prasert saichua1, paiboon sithithaworn2,3, amar r. Suppression of aquaporin, a mediator of water channel control. Infection with opisthorchis viverrini and its associated cholangiocarcinoma cca is an underestimated problem in the mekong region of southeast asia, despite the widespread use of praziquantel and. Opisthorchis viverrini is a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities such as hepatobiliary diseases and cholangiocarcinoma chca.
The three epidemiologically important opisthorchiidae liver flukes opisthorchis felineus, o. Opisthorchis viverrini infection in the snail and fish. Thinking beyond opisthorchis viverrini for risk of. Opisthorchis species are liver fluke parasites that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas in asia and europe where the parasite is found, including thailand, laos, cambodia, vietnam, germany, italy, belarus, russia, kazakhstan, and ukraine. However, parasitological stoolbased diagnosis can be unreliable in light infections. We aimed to assess the efficacy and safety of a single, oral dose of tribendimidine, compared with praziquantel administered in two doses, in participants with o viverrini infection.
Pdf opisthorchis viverrini and opisthorchiasis banchob. Opisthorchis felineus has been documented in at least 12 countries of the european union, belarus, ukraine, and in western siberia russia. Pdf fish sharing as a risk factor for opisthorchis viverrini infection. Opisthorchiasis caused by opisthorchis viverrini is a serious health issue in the mekong basin region, resulting in a high prevalence of cholangiocarcinoma. Affected individuals often have mixed infections with the liver fluke opisthorchis viverrini and minute intestinal flukes such. Opisthorchis viverrini medigoo health medical tests. May 14, 2014 opisthorchis viverrini is highly endemic in southeast asia, where more than 10 million people are infected 1, 2. Foodborne trematodes, opisthorchis viverrini, opisthorchiasis prevention. Cooccurrence of opisthorchiasis and diabetes exacerbates. Opisthorchis viverriniis a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities such as hepatobiliary diseases and cholangiocarcinoma. Pdf epidemiology of opisthorchis viverrini paiboon. The tumorigenic liver fluke opisthorchis viverrini multiple pathways.
Opisthorchis viverrini infection among migrant workers in. A biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis prasert saichua1, paiboon sithithaworn2,3. Residents of 20 districts in the province were invited to attend a mobile screening programme between 1990 and 2001. Frontiers granulin secreted by the foodborne liver. Liver flukes infect the liver, gallbladder, and bile duct in humans. Opisthorchis viverrini has a complex life cycle in which eggs are excreted in the feces of the final hosts, usually humans, with cats and more rarely dogs also acting in this role 6, 12. Opisthorchis viverriniis a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities. People are infected after eating raw or undercooked fish. Opisthorchis viverrini is remains a public health problem in thailand, particularly in the northeast and north region where has the high incident of chonalgiocarcinoma cca. Efficacy and safety of tribendimidine versus praziquantel. Although infections are identified throughout southeast asia, the epicenter is northeast thailand, where high prevalence coexists with a high. Repeated praziquantel treatment and opisthorchis viverrini infection.
Opisthorchiasis is caused by opisthorchis viverrini southeast asian liver fluke and o. Summary opisthorchis viverrini infections were established in immunologically intact and t cell deprived hamsters. Welcome to cdc stacks adult opisthorchis viverrini flukes. The carcinogenic liver fluke opisthorchis viverrini is a reservoir for species of helicobacter asian pac j cancer prev, 16 5, 17511758 introduction cholangiocarcinoma cca is highly prevalent in asian countries, particularly in thailand, china, taiwan and korea shin et al.
Nakhon phanom province had the highest prevalence of o. Fish sharing as a risk factor for opisthorchis viverrini infection. Welcome to cdc stacks adult opisthorchis viverrini. The opisthorchis viverrini genome provides insights into life. These pathogen safety data sheets, regulated under workplace hazardous materials information system whmis legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious microorganisms. Lowgrade endemicity of opisthorchiasis, yangon, myanmar.
Opisthorchiasis is a major public health problem in southeast asia. Liver flukes are platyhelminth parasites of the class trematoda, and opisthorchis viverrini o viverrini is a member of the family opisthorchiidae. The tumorigenic liver fluke opisthorchis viverrini. First report and molecular identification of opisthorchis viverrini infection in human communities from lower myanmar plos one, dec 2019 win pa pa aung, thi thi htoon, htay htay tin, kyi kyi thinn. Posterior probability pp support for each of these major clades was 1. If the inline pdf is not rendering correctly, you can download the pdf file here. Opisthorchis viverrini infection in the snail and fish intermediate. Opisthorchis viverrini genome provides insights into life in the bile duct. This hepatobiliary disease is linked to malignant cancer. Opisthorchis viverrini is a zoonotic liver fluke that causes opisthorchiasis among humans in endemic areas, such as northeastern thailand. Adult opisthorchis felineus major protein fractions deduced. All structured data from the file and property namespaces is available under the. Current high prevalences of strongyloides stercoralis and.
Imported opisthorchis viverrini and parasite infections from thai labourers in taiwan volume 67 issue 2 h. Opisthorchis viverrini and clonorchis sinensis a opisthorchis viverrini thailand is the most endemic country for opisthorchiasis due to o. Opisthorchis viverrini wikipedia, a enciclopedia livre. Efficacy and safety of tribendimidine against opisthorchis viverrini. Imported opisthorchis viverrini and parasite infections. Opisthorchiasis and opisthorchisassociated cholangiocarcinoma in. This is a particular problem in highly endemic areas for o. These species of flukes are classified as group i carcinogens by the international agency for research on cancer iarc. Deimert4, jiraporn sithithaworn5, banchob sripa6, thewarach laha2, eimorn mairiang7, chawalit pairojkul7, maria victoria periago8. Opisthorchis viverrini medigoo health medical tests and. Opisthorchis viverrini ov infection is one of the foodborne trematodiases, which is highly endemic in lao peoples democratic republic pdr. Opisthorchis viverrini, in the lower mekong region. Rapid labelfree analysis of opisthorchis viverrini eggs. Opisthorchis and metorchis, commonly referred to as liver flukes, are transmitted to humans and other mammals by the ingestion of fish infected with their larval stages which.
Media in category opisthorchis viverrini the following 7 files are in this category, out of 7 total. Pdf opisthorchis viverrini and opisthorchis felineus. Surveys of human fecal samples have frequently reported o. Infection is acquired when people ingest raw or undercooked fish. Opisthorchis viverrini is known as the southeast asian liver fluke and o.
Opisthorchis viverrini, a human liver fluke, is highly prevalent in southeast asia. Opisthorchiasis, caused by the liver fluke opisthorchis viverrini, is a major risk factor for cholangiocarcinoma 1. Opisthorchis viverrini, a foodborne trematode parasite endemic in the lower mekong countries, is conventionally diagnosed by stool examination. Select up to three search categories and corresponding keywords using the fields to the right. A recently established urine antigen detection test using monoclonal antibodybased enzymelinkedimmunosorbent assay mabelisa has shown promise due to its high diagnostic accuracy and the use of urine in place of fecal samples. Trematodes flukes opisthorchis viverrini southeast asian liver fluke and opisthorchis felineus cat liver fluke. Nov 16, 2017 praziquantel is the only option for treatment of the liver fluke infection opisthorchis viverrini. Infection with the parasite is called opisthorchiasis.
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